Presentation
- 10mg/1ml ampoule
- 10mg tablet
Note: Not interchangeable with vitamin K3
Role
Reversal of coagulopathy caused by warfarin and long-acting anticoagulant rodenticides or superwarfarins.
Consultation with a clinical toxicologist is recommended through the local toxicology service or Poisons Information Centre 13 11 26.
Dose
Active bleeding due to warfarin poisoning
- 10mg IV stat
Management of warfarin poisoning in asymptomatic patient
- 1-5mg IV/PO q6h guided by INR
Management of superwarfarin poisoning
- 50-100mg IV/PO stat then 50-200mg/day PO in divided doses aiming for an INR < 2. It is advised that these cases are discussed with a clinical toxicologist.
Stocking recommendations
| Tertiary centre | Regional centre | Rural centre | Remote centre |
|---|---|---|---|
| 20 ampoules / 100 tablets | 20 ampoules / 100 tablets | 5 ampoules | 0 ampoules |
Rationale
Vitamin K1 is readily available in most hospitals. The oral tablet preparation can be difficult to obtain; the IV formulation can be given orally if necessary.
Disclaimer
Fact sheet developed by Queensland Poisons Information Centre.
This fact sheet is about the use of these antidotes in Australia, and may not apply to other countries. Children’s Health Queensland Hospital and Health Service cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this fact sheet.
Last updated: July 2023